Konjac extract, its main efficacy components is ceramide, it naturally in human skin lipids in between the outer cuticle cells, prevent moisture distribution and the loss of nutrients, and the outside physical and chemical and biological stimuli are protective function.For skin protection, moisturizing and moisturizing are important.
Konjac ceramides is extracted from a plant named Konjac-tuber, which has been consumed for more than 1,000 years in China. It is widely used for functional foods, dietary supplemnts and skin care.
Specification: Konjac ceramides 5%, 90% by HPLC
Appearance: White to Off-white Powder(90%)
Botanical Source: Konjac-tuber
Catalogue No.: BPE020
Functions of our Konjac ceramides:
Control melanin pigmentation
Improve barrier effect against stimulants
Lower TEWL and keep the skin moisture
Support healthy and beautiful skin
1, Ceramides and skin function.
Am J Clin Dermatol. 2003;4(2):107-29
Ceramides are the major lipid constituent of lamellar sheets present in the intercellular spaces of the stratum corneum. These lamellar sheets are thought to provide the barrier property of the epidermis. It is generally accepted that the intercellular lipid domain is composed of approximately equimolar concentrations of free fatty acids, cholesterol, and ceramides. Ceramides are a structurally heterogeneous and complex group of sphingolipids containing derivatives of sphingosine bases in amide linkage with a variety of fatty acids. Differences in chain length, type and extent of hydroxylation, saturation etc. are responsible for the heterogeneity of the epidermal sphingolipids. It is well known that ceramides play an essential role in structuring and maintaining the water permeability barrier function of the skin. In conjunction with the other stratum corneum lipids, they form ordered structures. An essential factor is the physical state of the lipid chains in the nonpolar regions of the bilayers. The stratum corneum intercellular lipid lamellae, the aliphatic chains in the ceramides and the fatty acids are mostly straight long-chain saturated compounds with a high melting point and a small polar head group. This means that at physiological temperatures, the lipid chains are mostly in a solid crystalline or gel state, which exhibits low lateral diffusional properties and is less permeable than the state of liquid crystalline membranes, which are present at higher temperatures. The link between skin disorders and changes in barrier lipid composition, especially in ceramides, is difficult to prove because of the many variables involved. However, most skin disorders that have a diminished barrier function present a decrease in total ceramide content with some differences in the ceramide pattern. Formulations containing lipids identical to those in skin and, in particular, some ceramide supplementation could improve disturbed skin conditions. Incomplete lipid mixtures yield abnormal lamellar body contents, and disorder intercellular lamellae, whereas complete lipid mixtures result in normal lamellar bodies and intercellular bilayers. The utilization of physiological lipids according to these parameters have potential as new forms of topical therapy for dermatoses. An alternative strategy to improving barrier function by topical application of the various mature lipid species is to enhance the natural lipid-synthetic capability of the epidermis through the topical delivery of lipid precursors.
2, Improvement of Atopic Dermatitis and Reduction of Skin Allergic Responses by Oral Intake of Konjac Ceramide
Pediatric Dermatology (Impact Factor: 1.52). 07/2006; 23(4):386-9
Although topical application of ceramide is effective in the treatment of atopic dermatitis, its effect is transient. Thus, the effect of oral intake of ceramide on atopic dermatitis was studied. Two groups of 25 children with moderate atopic dermatitis, who were allergic to house dust mite took either milk sugar (control group) or 1.8 mg/day of konjac ceramide in milk sugar (ceramide group) once a day for 2 weeks. Before and after 2 weeks, skin symptoms were assessed using the SCORAD index, while allergic skin responses to house dust mite were assessed by skin prick test. Moreover, production of allergen-specific IgE and various cytokines by mononuclear cells was measured. After 2 weeks, SCORAD index score, allergic skin responses to house dust mite and house dust mite-specific IgE production were significantly reduced in the ceramide group, but not in the control group. Moreover, house dust mite-induced cytokine production was skewed towards the Th1 type, since production of Th1 cytokine, IFN-gamma, and IL-12, was increased, while production of Th2 cytokine, IL-4, and IL-13, was decreased. In contrast, no change of these parameters was found in control group. Collectively, oral intake of konjac ceramide improved skin symptoms and reduced allergic responses with concomitant skewing of the cytokine pattern towards the Th1 type.
3, Asai S, Miyachi H. “Evaluation of skin-moisturizing effects of oral or percutaneous use of plant ceramides.”
Rinsho Byori. 2007 Mar;55(3):209-15.
4, Choi MJ, Maibach HI. “Role of ceramides in barrier function of healthy and diseased skin.”
Am J Clin Dermatol. 2005;6(4):215-23.
5, Huang HC, Chang TM. “Ceramide 1 and ceramide 3 act synergistically on skin hydration and the transepidermal water loss of sodium lauryl sulfate-irritated skin.”
Int J Dermatol. 2008 Aug;47(8):812-9.
6, Mutanu Jungersted J, Hellgren LI, Høgh JK, Drachmann T, Jemec GB, Agner T. “Ceramides and barrier function in healthy skin.”
Acta Derm Venereol. 2010 Jul;90(4):350-3.
7, Analysis and Determination of Ceramide in Konjac by HPLC-ELSD
Chinese Journal of Biochemistry and Molecular Biol 2010, Vol. 26 Issue (02) :189-194