CAS No .: 5508-58 -7
Latin dzina: Andrographis paniculata (Burm.f) mwe
Part ntchito: therere lonse
Maonekedwe: kuwala zachikasu ufa woyera
Maselo chilinganizo: C20H30O5
Maselo Kulemera kwake: 350,455
Mayeso njira: HPLC
mfundo:
Andrographolide 50%
Andrographolide 98%
Andrographolide 99%
Andrographolide ndi labdane diterpenoid kuti ndicho bioactive zikuluzikulu za A. paniculata, komanso anazindikira mankhwala zomera Asia. Kumakhudza osiyanasiyana zochita achire, kuphatikizapo immunosuppressant, antithrombotic, odana ndi yotupa, antineoplastic, mavairasi oyambitsa, antibacterial, antidiabetic, nkhawa antioxidative, antipyretic, antioedematogenic, ndi antinociceptive activities.1Andrographolide chithandizo kumabwezera mmbuyo nyukiliya chinthu kappa B (NF-κB) chikugwirabe kuti ochirikiza DNA imene imachititsa chandamale (IC50 = ~ 15 μm), ndi kupanga covalent adduct ndi kuchepetsedwa cysteine (62) ya NF-κB p50 kagawo kakang'ono, ndipo angathe kupangira umboni wa CYP1A subfamily wa cytochrome P450 banja la michere. 2,3 pa 5 μg / g thupi akhoza kuletsa kutsegula kwa NF-κB mu analimbikitsa maselo za indofeliyamu, kuchepetsa mawu a khungu guluu wolimba molekyulu E-selectin, abrogating ndi cytokine- ndi endotoxin chovutika peritoneal kusalola neutrophils, attenuating septic mantha, ndi kuteteza matupi awo sagwirizana kutupa m'mapapo mu chitsanzo mbewa wa asthma.3
Mankhwala wazolongedza: 25kg / ng'oma
Nthawi n'loonadi: zaka 2
